Royal Air Force Typhoon jets have joined forces with France's air force in a joint strike on an hidden munitions depot in Syria operated by the IS group, as stated by the UK's MoD.
The facility, located using intelligence, was believed to be housing weapons and explosive materials, the statement said, and was situated in hills just above the historic site of Palmyra in Syria's central region.
"The RAF jets employed laser-guided Paveway IV weapons to hit a several access tunnels leading to the facility... initial indications suggest the objective was successfully hit," the ministry announced.
There was no evidence of any civilian impact in the operation on Saturday evening and each participating jet returned to base without incident, the defence officials confirmed.
The Typhoon FGR4s were assisted by a Voyager refuelling tanker.
Daesh - alternatively referred to as ISIS - imposed jihadist rule over significant areas in both Syria and Iraq until 2019.
"This operation underscores the UK's leading role, and commitment to stand shoulder to shoulder with allied nations, to eradicate any revival of the terrorist group and their dangerous and violent ideologies in the area," UK Defence Secretary John Healey stated.
UK warplanes have performed surveillance missions over Syria to "forestall any attempted resurgence" of Islamic State following its military defeat at the climactic battle in Baghuz in 2019, the ministry said.
"I want to thank every member of the UK armed forces who took part in this strike for their professionalism and their bravery," Healey said. "They were among numerous UK service members on duty over the holidays. This action, to take out dangerous terrorists who pose a risk to our safety, highlights how our armed forces are ready to step up, throughout the year, keeping Britain secure domestically and strong abroad."
During December, the American forces conducted what it termed a "large-scale strike" on IS targets in Syria, following an ambush killed two American soldiers and a civilian interpreter in Palmyra.
The United Nations says Islamic State still has between 5,000 and 7,000 militants in Iraq and Syria.